After issuing a volume of errata in 1904, the dictionary was reissued with minor revisions in 22 volumes in 1908 and 1909; a subtitle said that it covered British history "from the earliest times to the year 1900". In the words of the 1911 edition of the Encyclopædia Britannica, the dictionary had "elucidated the private annals of the British", providing not only concise lives of the notable deceased, but additionally lists of sources which were invaluable to researchers in a period when few libraries or collections of manuscripts had published catalogues or indices, and the production of indices to periodical literatures was just beginning. Throughout the twentieth century, further volumes were published for those who had died, generally on a decade-by-decade basis, beginning in 1912 with a supplement edited by Lee covering those who died between 1901 and 1911. The dictionary was transferred from its original publishers, Smith, Elder and Co., to Oxford University Press in 1917. Until 1996, Oxford University Press continued to add further supplements featuring articles on subjects who had died during the 20th century.
The supplements published between 1912 and 1996 added about 6,000 lives of people who died in the 20th century to the 29,120 in the 63 volumes of the original DNB. In 1993 a volume containing missing persons was published. This had an additional 1,000 lives, selected from over 100,000 suggestions. This did not seek to replace any articles on existing DNB subjects, even though the original work had been written from a Victorian perspective and had become out of date in that it could not take into account changes in historical assessments and discoveries of new information during the twentieth century. Consequently, the dictionary was becoming less and less useful as a reference work.
The new dictionary would cover British history, "broadly defined" (including, for example, subjects from Roman Britain, the United States of America before its independence, and from Britain's former colonies, provided they were functionally part of the Empire and not of "the indigenous culture" (Introduction)) up to 31 December 2000. The research project was conceived as a collaborative one, with in-house staff co-ordinating the work of nearly 10,000 contributors internationally. It would remain selective - there would be no attempt to include all members of parliament, for example - but would seek to include significant, influential or notorious figures from the whole canvas of the life of Britain and its former colonies, overlaying the decisions of the late-nineteenth-century editors with the interests of late-twentieth-century scholarship in the hope that "the two epochs in collaboration might produce something more useful for the future than either epoch on its own", but acknowledging also that a final definitive selection is impossible to achieve.
Following Matthew's death in October 1999, he was succeeded as editor by another Oxford historian, Professor Brian Harrison, in January 2000.
The new dictionary, now known as the Oxford Dictionary of National Biography (or ODNB), was published on 23 September 2004 in 60 volumes in print at a price of £7500, and in an online edition for subscribers. The print edition is currently selling for £6500. At publication, the 2004 edition had 50,113 biographical articles covering 54,922 lives, including entries on all subjects included in the old DNB. (The old DNB entries on these subjects may be accessed separately through a link to the "DNB Archive" – many of the longer entries are still highly regarded.) A small permanent staff remain in Oxford to update and extend the coverage of the online edition. Brian Harrison was succeeded as editor by another Oxford historian, Dr Lawrence Goldman, in October 2004. The first online update was published on 4 January 2005, including subjects who had died in 2001. A further update, including subjects from all periods, followed on 23 May 2005, and another on 6 October 2005. New subjects who died in 2002 were added to the online dictionary on 5 January 2006, with continuing releases in May and October in subsequent years following the precedent of 2005.
The online version has an advanced search facility, allowing a search for people by area of interest, religion and "Places, Dates, Life Events". This accesses an electronic index that cannot be directly viewed.
Response to the new dictionary has been for the most part positive, but in the months following publication there was occasional criticism of the dictionary in some British newspapers and periodicals for reported factual inaccuracies. However, the number of articles publicly queried in this way was small — only 23 of the 50,113 articles published in September 2004, leading to fewer than 100 substantiated factual amendments. These and other queries received since publication are being considered as part of an ongoing programme of assessing proposed corrections or additions to existing subject articles, which can, when approved, be incorporated into the online edition of the dictionary. In 2005, The American Library Association awarded the Oxford Dictionary of National Biography its prestigious Dartmouth Medal.
Contents of each volume of the first series with year of publication and editor.
| Names | Year Pub. | Editor |
| Abbadaire - Anne | 1885 | Stephen |
| Annesley - Baird | ||
| Baker - Beadon | ||
| Beal - Biber | ||
| Bicheno - Bottasham | 1886 | |
| Bottomley - Browell | ||
| Brown - Burthogge | ||
| Burton - Cantwell | ||
| Canute - Challoner | 1887 | |
| Chamber - Clarkson | ||
| Clater - Condell | ||
| Condor - Craige | ||
| Craike - Damer | 1888 | |
| Damon - D'Eyncourt | ||
| Diamond - Drake | ||
| Drant - Eldridge | ||
| Edward - Erskine | 1889 | |
| Esdale - Finan | ||
| Finch - Forman | ||
| Forrest - Garner | ||
| Garnet - Gloucester | 1890 | |
| Glover - Grovet | Stephen
|
|
| Gray - Haighton | ||
| Hales - Harriott | ||
| Harris - Henry I | 1891 | |
| Henry II - Hindley | ||
| Hindmarsh - Hovenden | Lee | |
| Howard - Inglethorpe | ||
| Inglish - John | 1892 | |
| Johnes - Kenneth | ||
| Kennett - Lambert | ||
| Lambe - Leigh | ||
| Leichton - Lluelyn | 1893 | |
| Llywd - MacCartney | ||
| MacCarwell - Maltby | ||
| Malthus - Mason | ||
| Masquerier - Millyng | 1894 | |
| Milman - More | ||
| Morehead - Myles | ||
| Mylar - Nicholls | ||
| Nichols - O'Dugan | 1895 | |
| O'Duinn - Owen | ||
| Owens - Passelene | ||
| Paston - Percy | ||
| Pereira - Pockrich | 1896 | |
| Pocock - Puckering | ||
| Puckle - Reidford | ||
| Reilly - Robins | ||
| Robinson - Russell | 1897 | |
| Russen - Scobell | ||
| Scoffin - Sheares | ||
| Sherman - Smirke | ||
| Smith - Stanger | 1898 | |
| Stanhope - Stovin | ||
| Stow - Taylor | ||
| Teach - Tollet | ||
| Tom - Tytler | 1899 | |
| Ubaldini - Wakefield | ||
| Wakeman - Watkins | ||
| Watson - Whewell | ||
| Whichcord - Williams | 1900 | |
| Williamson - Worden | ||
| Wordsworth - Zuylestein |