Her parents' tumultuous marriage lasted only a few years and they divorced when she was four. Educated in Paris, France and at schools in New York City, she had little contact with her estranged father, a situation exacerbated by her mother's bitterness towards him. Her parenting was left to boarding schools and nannies.
Her father died in 1942 from cirrhosis of the liver after years of alcoholism. Barrymore's life became a series of alcohol and drug related disasters marked by bouts of severe depression that resulted in several suicide attempts and extended sanitarium stays. She squandered her movie earnings and her inheritance from her father's estate, and when her mother died in 1950 she was left with virtually nothing from a once vast family fortune.
After three bad marriages to addicted and sometimes abusive men, in 1955 Barrymore had herself hospitalized for nearly a full year of treatment. In 1957, she published her autobiography, Too Much, Too Soon, and the following year Warner Bros. made a film with the same title starring Dorothy Malone as Diana and Errol Flynn as her father.
| Year | Title | Role | Other notes |
| 1941 | Manpower | Bit Part | |
| 1942 | Eagle Squadron | Anne Partridge | |
| 1942 | Between Us Girls | Caroline Bishop | |
| 1942 | Nightmare | Leslie Stafford | |
| 1943 | Frontier Badmen | Claire | |
| 1943 | Fired Wife | Eve | |
| 1944 | Ladies Courageous | Nadine Shannon | |
| 1944 | The Adventures of Mark Twain | (uncredited) | |
| 1950 | D.O.A. | (uncredited) | |
| 1951 | The Mob | (uncredited) |