Dess-Martin periodinane is a chemical reagent used to oxidize primary alcohols to aldehydes and secondary alcohols to ketones. This periodinane has several advantages over chromium- and DMSO-based oxidants that include milder conditions, shorter reaction times, higher yields, and simplified workups. It is named after the American chemists Daniel Benjamin Dess and James Cullen Martin.
To avoid the explosive nature of 2-iodoxybenzoic acid, other methods of preparation as well as other periodinanes have been described.
Its effectiveness as an oxidant is also due to its versatility; having a broad scope of being able to convert alcohols to carbonyl derivatives. Its reactions and yield are also known to be clean and high respectively. Work up is also clean and simple. Byproducts from the reaction can be removed easily by precipitation, filtration or chromatography.