Their self-titled debut album was released in 2003. All lyrics on the earlier albums are sung in Khmer, whilst the third album introduces some songs in English. Many of the songs are covers of 1960s Cambodian rock tunes by such artists as Sinn Sisamouth and Ros Sereysothea, but some are originals, first written in English by the Holtzmans before being translated.
Their second album, Escape from Dragon House, was released in 2005, and contained more original songs. It was re-released on limited edition colored vinyl on August 26th, 2008. Escape from Dragon House was one of Amazon.com's Top 100 Editor's Picks of 2005.
In June 2008, Real World Records released “Venus On Earth” in all territories outside of the U.S. and Canada. Peter Gabriel founder of Real World Records said this of the deal: "We have Dengue Fever coming out on Real World Records (outside of the USA) - it’s really cool stuff, with the small Cambodian singer and big American guys behind! They’re California based but have taken 60’s Cambodian pop as their main source of inspiration and it’s done with a lot of style. It’s spirited, impassioned stuff."
"Ethanopium", a cover of a song by Ethiopian jazz musician Mulatu Astatke, was included in the soundtrack of Jim Jarmusch's 2005 film, Broken Flowers.
"One Thousand Tears of a Tarantula" was included on the soundtrack for the second season of the Showtime series "Weeds"
"Both Sides Now", a Joni Mitchell cover, was included on the soundtrack of Matt Dillon's 2002 film, City of Ghosts.
"Escape From Dragon House" was featured in an episode of the same name on the HBO show "True Blood."
SuicideGirls interview with Ethan Holtzman