Through their work in the Shindogs, Delaney and Leon Russell had many connections in the music business, and were able to quickly form a band of solid, if transient, musicians around Delaney and Bonnie. The band became known as "Delaney & Bonnie and Friends" due to its regular changes of personnel. They secured a recording contract with Stax Records, and released their first album, Home, on Stax in early 1969. The album was not successful - perhaps due to poor promotion, as it was one of 27 albums simultaneously released by Stax in that label's attempt to establish itself in the album market.
Delaney and Bonnie moved to Elektra Records for their second album, Accept No Substitute (1969). While not a big seller either, Accept No Substitute created a buzz in music industry circles when, upon hearing pre-release mixes of the album, George Harrison offered Delaney and Bonnie a contract with the Beatles' Apple Records label - which Delaney and Bonnie signed despite their prior contractual commitment to Elektra. Although the Apple contract was subsequently voided, this incident began a falling-out between Delaney and Elektra, culminating in the band's release from their Elektra contract in late 1969.
On the strength of Accept No Substitute, and at his friend Harrison's suggestion, Eric Clapton took Delaney & Bonnie and Friends on the road in mid-1969 as the opening act for his band Blind Faith. Clapton became fast friends with Delaney, Bonnie and their band, preferring their music to Blind Faith's; he would often appear on stage with Delaney & Bonnie and Friends during this period, and continued to record and tour with them following Blind Faith's August 1969 breakup. Clapton helped broker a new record deal for Delaney and Bonnie with his then-US label, Atco (Atlantic) Records, and appears (with Harrison, Dave Mason, and others) on Delaney and Bonnie's third album, the live On Tour with Eric Clapton (Atco; recorded in the UK 7 December 1969, released June 1970). This album would be the most successful of Delaney and Bonnie's career, reaching #29 on the Billboard album charts. Clapton also recruited Delaney and Bonnie and their band to back him on his debut solo album, recorded in late 1969/early 1970 and produced by Delaney.
Delaney and Bonnie continued to make well-regarded, if modestly-selling, albums over the rest of their career. Their next two Atco albums, To Bonnie from Delaney (1970) and the largely-acoustic Motel Shot (1971) charted, and "Never Ending Song of Love," a single taken from Motel Shot, was Billboard's #67 single of 1971. The band also made a cameo appearance in Richard C. Sarafian's film Vanishing Point (1971), and performed a live radio broadcast for New York's WABC-FM (now WPLJ), backed by Duane Allman, Gregg Allman and (in one of his last performances) King Curtis, in July 1971. (The latter, while never officially released on album as Elton John's 11-17-70 show from the same concert series was, has been heavily bootlegged over the years and remains readily available.) By late 1971, however, Delaney and Bonnie's often-tempestuous relationship began to show signs of strain. Their next album was rejected by Atco on grounds of poor quality, with Atco/Atlantic electing to sell Delaney and Bonnie's recording contract - including this album's master tapes - to CBS as a result. Columbia/CBS released this album, in a different track sequence from that submitted to Atco, as D&B Together in March 1972. It would be Delaney and Bonnie's last album of new material, as the couple divorced in 1973.
Delaney and Bonnie continued to work in the music business - and, in Bonnie's case, in Hollywood as an actress - after their breakup. Delaney's recent appearances on record include the solo album A New Kind of Blues (2008) and Jerry Lee Lewis's Last Man Standing (2006). Bonnie enjoyed success during the late 1970s and early 80's as a backing singer with Stephen Stills and with The Allman Brothers Band; she subsequently turned to acting, appearing (as Bonnie Sheridan) in a recurring role on the TV series Roseanne (1991-95). Her most recent album is 2005's Roots, Blues & Jazz.
Besides their recorded legacy, Delaney and Bonnie influenced many fellow musicians of their era. Most notably, Eric Clapton has said that "Delaney taught me everything I know about singing, and Delaney has been cited as the person who taught George Harrison how to play slide guitar, an instrument Harrison used to great effect throughout his solo recording career. Bonnie, for her part, is credited as co-author of many popular songs, including "Groupie (Superstar)" (a Top 10 hit for The Carpenters in 1971; also covered by ex-Delaney and Bonnie backing vocalist Rita Coolidge, Bette Midler, Sonic Youth and many others) and Clapton's "Let It Rain." (Bonnie's song authorship has in recent years become a matter of dispute, with Delaney claiming that he wrote many of these songs but assigned ownership to Bonnie to dodge an onerous publishing contract - an assertion given credence, indirectly, through statements made by Clapton.)
Delaney and Bonnie's "friends" of the band's 1969-70 heyday also had considerable impact. After the early 1970 breakup of this version of the band, many of its ex-members were recruited by Leon Russell to join Joe Cocker's band, participating on Cocker's Mad Dogs and Englishmen recording sessions and North American tour (March-May 1970; Rita Coolidge's version of "Groupie (Superstar)" was recorded with this band while on tour). Following this, these same musicians, joined by Eric Clapton and Dave Mason, also comprised the core backing band on George Harrison's vocal debut album All Things Must Pass (1970). Clapton subsequently recorded his landmark album Layla and Other Assorted Love Songs (1970) with this band's bassist Carl Radle, singer/keyboardist Bobby Whitlock and drummer Jim Gordon, as Derek and the Dominos.
Finally, Delaney and Bonnie's daughter Bekka Bramlett is active in the music business as well. Bekka briefly sang lead with Fleetwood Mac in the early 1990s, and has since pursued a successful career as a backing vocalist, most notably with Faith Hill.
In addition, GNP Crescendo Records (US) and London Records (UK) released an album of 1967-68 recordings by Delaney Bramlett in 1971 as Delaney & Bonnie: Genesis. While not a Delaney & Bonnie album per se, Bonnie Bramlett does appear with Delaney on three of this album's twelve selections.