Deacetylcephalosporin-C_acetyltransferase

Deacetylcephalosporin-C acetyltransferase

In enzymology, a deacetylcephalosporin-C acetyltransferase is an enzyme that catalyzes the chemical reaction

acetyl-CoA + deacetylcephalosporin C rightleftharpoons CoA + cephalosporin C

Thus, the two substrates of this enzyme are acetyl-CoA and deacetylcephalosporin C, whereas its two products are CoA and cephalosporin C.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:deacetylcephalosporin-C O-acetyltransferase. Other names in common use include acetyl-CoA:deacetylcephalosporin-C acetyltransferase, DAC acetyltransferase, cefG, deacetylcephalosporin C acetyltransferase, acetyl coenzyme A:DAC acetyltransferase, acetyl-CoA:DAC acetyltransferase, CPC acetylhydrolase, acetyl-CoA:DAC O-acetyltransferase, and DAC-AT. This enzyme participates in penicillin and cephalosporin biosynthesis.

References

  • S "Purification of acetyl coenzyme A: deacetylacephalosporin C O-acetyltransferase from Acremonium chrysogenum". Biosci. Biotechnol. Biochem. 56 1410–2.
  • Gutierrez S, Velasco J, Fernandez FJ, Martin JF "The cefG gene of Cephalosporium acremonium is linked to the cefEF gene and encodes a deacetylcephalosporin C acetyltransferase closely related to homoserine O-acetyltransferase". J. Bacteriol. 174 3056–64.
  • K "Cloning and disruption of the cefG gene encoding acetyl coenzyme A: deacetylcephalosporin C o-acetyltransferase from Acremonium chrysogenum". Biochem. Biophys. Res. Commun. 186 40–6.
  • JL, Diez B, Martin JF "Expression of the cefG gene is limiting for cephalosporin biosynthesis in Acremonium chrysogenum". Appl. Microbiol. Biotechnol. 48 606–14.
  • Velasco J, Gutierrez S, Campoy S, Martin JF "Molecular characterization of the Acremonium chrysogenum cefG gene product: the native deacetylcephalosporin C acetyltransferase is not processed into subunits". Biochem. J. 337 379–85.
  • AT, Kosalkova K "Expression of genes and processing of enzymes for the biosynthesis of penicillins and cephalosporins". Antonie. Van. Leeuwenhoek. 65 227–43.

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