His most famous works include two noted runs on the Iron Man series, with co-writer (and inker) Bob Layton, in the late 1970s and early 1980s which introduced the character's serious problem with alcoholism, his specialized power armor variants and his new enmities with Justin Hammer and Victor Von Doom. He also introduced one of Stark's closest comrade, the fearless pilot, Jim Rhodes. His most noted cliffhanger was when Tony Stark was thrown out of S.H.I.E.L.D.'s helicarrier and had to don his armor completely to use its flight function before he hit the ground.
In the late 1980s, he also wrote a popular run on The Amazing Spider-Man series which featured the art of Todd McFarlane, Erik Larsen and introduced the popular supervillain Venom. Michelinie had planned to introduce Venom earlier and did include a "teaser" scene in Web of Spider-Man #18, in which Peter Parker is pushed by an offscreen Venom into the path of an oncoming train, the symbiote being immune to Spider-Man's "spider sense" that would have normally warned him of the attack. This was the first of what was to be several clues leading to the reveal of Venom. Michelinie left Web of Spider-Man shortly after and was not able to continue the introduction of Venom until his time of writing on The Amazing Spider-Man, which started with issue #290. Subsequently he became the writer of Action Comics following Roger Stern's lengthy run, which ended with #700. He also worked at Valiant Comics on the books Rai and H.A.R.D. Corps.
In the credits of numerous comics, his name is misspelled as "David Micheline".