In his career, Ferretti has worked with many great directors, both American and European, such as Pier Paolo Pasolini, Federico Fellini, Terry Gilliam, Franco Zeffirelli, Martin Scorsese, Anthony Minghella, Tim Burton.
Ferretti has developed a very close professional relationship with Martin Scorsese, designing seven of his last eight movies. In the past he had two other long collaborations with Pier Paolo Pasolini and Federico Fellini, both with five films.
In 2008, he designed the set for Howard Shore's opera The Fly, directed by David Cronenberg, at the Théâtre du Châtelet in Paris.
Ferretti won two Academy Awards for Art Direction for the The Aviator and Sweeney Todd. He had seven previous nominations. In addition he was nominated for Best Costume Design for Kundun. He also won three BAFTA Awards.