Tamberelli played Little Pete on the Nickelodeon television show The Adventures of Pete & Pete and provided the voice for Arnold in The Magic School Bus, as well as appearing in the films Igby Goes Down and The Mighty Ducks. Many may also know him for his work on Nickelodeon's All That, as well as Figure It Out. He is known as the Nickelodeon "One Man Wrecking Crew" because he is known for killing shows, such as All That. He also guest starred, along with Michelle Trachtenberg, on an episode of Space Cases entitled "All You Can Eaty."
At a young age Danny played Jackie Rodowsky on the TV show The Baby-Sitters Club.
Tamberelli is a graduate of Hampshire College, where he earned a bachelor's degree in Interdisciplinary Arts focusing on music performance and booking management. He now is the bassist and vocalist for the rock band Jounce. They have recently released an eponymous debut album. He is also the bassist for the Folk/Pop band Every Good Boy.
He was in a commercial for Lego Pirate toys in the 1990s.
He most recently (2006) appeared in a commercial for Wendy's fast food.
Danny Tamberelli was the answer to the $25,000 question on a recent episode of the Singaporean version of "Who Wants to be a Millionaire. The question was answered incorrectly by Adam Shreve.