DOCK (protein)

DOCK (Dedicator of cytokinesis) is a family of related proteins involved in intracellular signalling networks. Studies to date suggest that this family act as guanine nucleotide exchange factors for small G proteins of the Rho family, such as Rac and Cdc42. DOCK family proteins are categorised into four subfamilies based on their sequence similarity:

• DOCK-A subfamily
• Dock180 (also known as Dock1)
• Dock2
• Dock5
• DOCK-B subfamily
• Dock3 (also known as MOCA and PBP)
• Dock4
• DOCK-C subfamily (also known as Zir subfamily)
• Dock6 (also known as Zir1)
• Dock7 (also known as Zir2)
• Dock8 (also known as Zir3)
• DOCK-D subfamily (also known as Zizimin subfamily)
• Dock9 (also known as Zizimin1)
• Dock10 (also known as Zizimin3)
• Dock11 (also known as Zizimin2)

References