Organic compound of the pyrimidine family, often called a base, consisting of a single ring, containing both nitrogen and carbon atoms, and an amino group. It occurs in combined form in nucleic acids and several coenzymes. In DNA its complementary base is guanine. It or its corresponding nucleoside or nucleotide may be prepared from DNA by selective techniques of hydrolysis.
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Cytosine is one of the five main bases found in DNA and RNA. It is a pyrimidine derivative, with a heterocyclic aromatic ring and two substituents attached (an amine group at position 4 and a keto group at position 2). The nucleoside of cytosine is cytidine. In Watson-Crick base pairing, it forms three hydrogen bonds with guanine.
Cytosine recently found use in quantum computation. The first time any quantum mechanical properties were harnessed to process information took place on August 1st in 1998 when researchers at Oxford implemented David Deutsch's algorithm on a two qubit NMRQC (Nuclear Magnetic Resonance Quantum Computer) based on the cytosine molecule.
In DNA and RNA, cytosine is paired with guanine. However, it is inherently unstable, and can change into uracil (spontaneous deamination). This can lead to a point mutation if not repaired by the DNA repair enzymes such as uracil glycosylase, which cleaves a uracil in DNA.
Genome-Wide Variation of Cytosine Modifications between European and African Populations and the Implications for Complex Traits
Aug 01, 2013; ABSTRACT Elucidating Cytosine modification differences between human populations can enhance our understanding of ethnic...
SYNTHESIS OF N^sup 4^-SUBSTITUTED DERIVATIVES OF 1-[2-(PHOSPHONOMETHOXY)ETHYL]CYTOSINE AND ITS DIISOPROPYL ESTER AS A MODEL REACTION FOR THE SYNTHESIS OF N^sup 4^-SUBSTITUTED DERIVATIVES OF CIDOFOVIR
Dec 01, 2005; We have studied the reaction of 1-[2-(phosphonomethoxy)ethyl]Cytosine (1) and its diisopropyl ester (2) with...