The highway begins in Brisbane where it is known as Ipswich Road, which turns into the M2 Ipswich Motorway. After the Warrego Highway turnoff, it is then known as the Cunningham Highway. It runs south-west from Brisbane for approximately 330 km until it terminates at Goondiwindi. It is route number 15 until Warwick where it then becomes route 42.
The M5 Centenary Motorway extension from Springfield will join the Cunningham Freeway. This corridor is currently being finalised. It is also expected to have additional space for expansion and a possible rail loop link to Ipswich-Springfield.