According to the United States Census Bureau, the city has a total area of 4.9 square miles (12.8 km²), of which, 4.9 square miles (12.8 km²) of it is land and 0.04 square miles (0.1 km²) of it (0.40%) is water.
There were 2,500 households out of which 33.0% had children under the age of 18 living with them, 47.2% were married couples living together, 16.0% had a female householder with no husband present, and 32.2% were non-families. 29.2% of all households were made up of individuals and 16.6% had someone living alone who was 65 years of age or older. The average household size was 2.54 and the average family size was 3.13.
In the city the population was spread out with 27.1% under the age of 18, 8.5% from 18 to 24, 24.4% from 25 to 44, 20.3% from 45 to 64, and 19.7% who were 65 years of age or older. The median age was 38 years. For every 100 females there were 86.1 males. For every 100 females age 18 and over, there were 80.6 males.
The median income for a household in the city was $24,931, and the median income for a family was $29,500. Males had a median income of $26,154 versus $16,551 for females. The per capita income for the city was $14,286. About 21.5% of families and 26.8% of the population were below the poverty line, including 34.6% of those under age 18 and 20.1% of those age 65 or over.
The city of Cuero had its start in the mid 19th century as a stopping point on the Chisholm Trail cattle route to Kansas. However, it wasn't recoginzed as a town until 1873 when it was officially founded. The city was named for the Spanish word meaning "hide", referring to the leather made from animal hides. The industry was extremely short-lived, however, and gave way to various forms of ranching. The city's population grew considerably in the 1870s and 1880s as residents from the coastal town of Indianola, Texas settled here after major hurricanes in this period destroyed sizeable portions of their city. The city thrived through much of the late 19th and early 20th century by the introduction and practice of turkey ranching in the area. Today, agriculture is still the primary industry in the Cuero region. Cuero is considered to be one of the top cattle producers and shippers in Texas. Recently, on August 8, 2008, a DeWitt County deputy, Brandon Riedel, filmed an unidentifiable animal along back roads near Cuero, Texas on his dashboard camera. It is said to be the mythical chupacabra.
Cuero was the birthplace of Leo Frank.
The animal found by Phylis Canion was likely the Mexican Hairless Dog, a rare breed found in Mexico and not the mythical Chupacabra as reported by Foxnews.com. 
On August 8, 2008, a Dewitt County deputy, Corporal Brandon Riedel, filmed an unidentifiable animal along back roads near Cuero, Texas on his dashboard camera. The animal was about the size of a coyote but was hairless with a long snout, short front legs and long back legs. The footage was clear and in daylight, however the animal was running in front of and away from the police cruiser so it is difficult to discern most of its features; however at one point it briefly looks over its shoulder, revealing what seems to be a very elongated snout. Riedel commented that it didn't seem to be running like a dog or coyote, which run in a more smooth motion, and instead in the footage it is running in a galloping motion. However, Reiter's boss, Sherrif Jode Zavesky, believes it may be a coyote similar to the one identified by Texas State University–San Marcos researchers in November 2007.