Convict Van Duff is the leader of a large-scale prison break. The breakout works as the six survivors hide out in a forgotten mine working near the prison.
Once the coast is clear they then set out on a long, dangerous journey. The convicts take by foot, car, train and truck in an attempt to get to some hidden stolen bank loot. On the journey the doomed prisoners meet with some locals including a kidnapped doctor (Percy Helton) and a young woman on a train (Gloria Talbott).