is a type of accidental cell death
typically caused by ischemia
It is characterised by the 'ghostly' appearance of cells under light microscopy in the affected area of tissue. Like most types of necrosis if enough labile cells are present around the affected area regeneration can occur.
Coagulative necrosis is most commonly caused by hypoxic
conditions, which don't involve severe trauma
or an acute
or chronic immune response
. The lack of oxygen causes cell death in a localised area which is perfused by blood vessels failing to deliver primarily oxygen, but also other important nutrients. It is important to note that while ischemia in most tissues of the body will cause coagulative necrosis, in the central nervous system ischemia causes liquefactive necrosis
as there is very little structural framework in the brain tissue.
The macroscopic appearance of an area of coagulative necrosis is a pale segment of tissue contrasting against surrounding well vascularised tissue and is dry on cut surface. The tissue may later turn red due to inflammatory response. The surrounding surviving cells can aid in regeneration of the affected tissue unless they are stable
The microscopic anatomy shows a lighter staining tissue (when stained with H&E
) containing no nuclei with very little structural damage giving the appearance often quoted as 'ghost cells'. The decreased staining is due to digested nuceli which no longer show up as dark purple when stained with hematoxylin
and removed cytoplasmic structures giving reduced amounts of intracellular protein reducing the usual dark pink staining cytoplasm with eosin
As the majority of the structural remnants of the necrotic tissue remains, labile cells adjacent to the affected tissue will replicate and replace the cells which have been killed during the event. Labile cells are constantly undergoing mitosis
and can therefore help reform the tissue, whereas nearby stable and permanent cells (eg. neurons
) do not undergo mitosis and will not replace the tissue affected. Fibroblasts
will also migrate to the affected area depositing fibrous tissue producing fibrosis
in areas where labile cells do not replicate and replace tissue.