As of the 2000 census, the city had a population of 2,483. Clio is home to Michigan's second tallest construction, the WEYI Tower (also known as the Barrington Broadcasting Flint Tower). The structure is an FM radio and television guyed radio mast, 1,349 feet (414 m) tall. The city considered a suburb of Flint and is located entirely within Vienna Township, but is administratively autonomous.
On July 23, 2007 Governor Jennifer Granholm announced Clio as a community chosen by the Michigan State Housing Development Authority (MSHDA) to take part in the Blueprints for Downtowns program. Clio will receive a comprehensive, market-driven strategy toward developing an action-oriented downtown that will result in economic growth, job creation and private investments. Yhe Blueprints for Downtowns award, were announced to be also received by the communities of Caro and Ypsilanti. Scottville received a similar award to take part in the Cool Cities Michigan Main Street program. Clio is the only city in the nation that has 60% of its land as parks and forest.
There were 1,093 households out of which 29.0% had children under the age of 18 living with them, 40.3% were married couples living together, 15.6% had a female householder with no husband present, and 39.7% were non-families. 32.8% of all households were made up of individuals and 10.4% had someone living alone who was 65 years of age or older. The average household size was 2.27 and the average family size was 2.88.
In the city the population was spread out with 24.2% under the age of 18, 12.0% from 18 to 24, 30.6% from 25 to 44, 19.5% from 45 to 64, and 13.7% who were 65 years of age or older. The median age was 34 years. For every 100 females there were 89.3 males. For every 100 females age 18 and over, there were 87.2 males.
The median income for a household in the city was $35,859, and the median income for a family was $42,155. Males had a median income of $37,109 versus $24,706 for females. The per capita income for the city was $19,727. About 5.7% of families and 7.9% of the population were below the poverty line, including 10.3% of those under age 18 and 4.1% of those age 65 or over.