Claude, Duke of Aumale

On August 1, 1547, he married Louise de Brézé (c. 1518 – January 1577), Lady of Anet, the daughter of Louis de Brézé, seigneur d'Anet, and Diane de Poitiers. They had eleven children:

• Henri (October 21, 1549, Château de Saint-Germain – August 1559), Count of Valentinois
• Charles, Duke of Aumale (1555–1631)
• Antoine (b. November 12, 1562), d. young
• Claude (December 13, 1564 – January 3, 1591, Saint-Denis), called the "Chevalier d'Aumale", Abbot of St.-Pere-en-Valle, Chartres, Knight of the Order of Malta, General of the Galleys
• Charles (January 25, 1566 – May 7, 1568, Paris)
• Catherine Romula (November 8, 1550, Saint-Germain – June 25, 1606), married on May 11, 1569 Nicholas, Duke of Mercoeur
• Madeleine Diane (b. February 5, 1554), d. young
• Diane (November 10, 1558 – June 25, 1586, Ligny), married on November 13, 1576 François, Duke of Piney-Luxemburg
• Antoinette (b. June 9, 1560, Nancy), d. young
• Antoinette Louise (September 29, 1561, Joinville – August 24, 1643, Soissons), Abbess of Soissons
• Marie (June 10, 1565 – January 27, 1627), Abbess of Chelles

In 1550, his brother Francis acceded as Duke of Guise and ceded to him the title of Duke of Aumale. He was killed by a culverin shot while besieging La Rochelle.