In the 1940s, Sanoja begins his experience at the radio at the program, Cada Minuto una Estrella, of Libertador Broadcasting. Later moving to Tropical Broadcasting, where he meets entertainer Amador Bendayán. 1944 and 1945, are vital in the formation of Sanoja as arranger, at the Luis Alfonzo Larrain Orchestra, he met José Perez Figuera, arranger of the group and the man responsible for Sanoja for the knowledge of arrangement . For this reason he soon receives the opportunity to make arrangements for Larrain, continuing with similar works for Billo Frómeta. In 1951 Chucho Sanoja decides to create his own orchestra, next to his brother Tomás Sanoja, acting with regularity at the Venezuela and Continente Broadcasting Radios, besides participating in major events, such as the inauguration of the Tamanaco Hotel in Caracas, and the Army Officer's Clubs in different regions of Venezuela, alternating with the Billo' s Caracas Boys, Havana Cuban Boys and Xavier Cugat. 1955 was an important year for Venezuelan authors as Sanoja altoghether with Luis Alfonzo Larrain and other authors, created Sacven the Venezuelan Author Rights Society. The first work undertaken by this society in defense of the Venezuelan author was preparing a bill with the aim of reforming the 1928 laws on intellectual property. This initiative, among others, prompted the legislative process that culminated in the adoption of the law on copyright in 1963.
In the 1960s, Chucho Sanoja and his orchestra, travels around Mexico, Colombia and Spain, also participates in the famous Caracas carnivals, alternating with the Orchestra of Tito Rodriguez at the Ávila Hotel, this friendly duel of orchestras, was recording in the album: En el Hotel Ávila Sigue la Cosa (1964). The trajectory and prestige of Chucho Sanoja, caused that Renny Ottolina contracted him, like musical director of his show on RCTV. At the end of this decade, Sanoja dissolves the orchestra and dedicates to the publicity, although for 1975 regroups it to record a new album. By this orchestra, passed many famous singers, some of them: Victor Piñero, Manolo Monterrey, Kiko Mendive, Alberto Beltrán, Víctor Pérez, Nelson Pinedo, Chico Salas, Héctor Barinas, Daniel Montes de Oca, among others.
His work like pianist and arranger were recognized, in addition to the sonorous personality of his orchestra, innovating with saxophones and flutes. Will be remembered for compositions like: Magia blanca, En la soledad, Maracaibo, Te pude alcanzar, to mention some, also by the enthusiasm that transmitted on his musical works, and the versions of popular songs like Lamento náufrago, Ya voy hacia ti, and Plena española. On December 11, 1998, Chucho Sanoja dies in Caracas.