Several years before her death, Chubbuck had moved into the family's summer cottage on Siesta Key, Florida. The Washington Post would later report that her painted bedroom and canopied bed looked like a young teenager's. After the divorce of Christine's parents, her mother Peg and younger brother Greg came to live in the Florida home. When Greg left, her elder brother Timothy moved in. She had a close relationship with her family, describing her mother and Greg as her closest friends.
Chubbuck volunteered at Sarasota Memorial Hospital, giving puppet shows to developmentally disabled children, and occasionally incorporated the homemade puppets into her WXLT-TV talk show.
WXLT-TV owner Bob Nelson had initially hired Chubbuck as a reporter, but later gave her a community affairs talk show, "Suncoast Digest", which ran in the morning after the national feed of The PTL Club. Production Manager Gordon J. Acker described Chubbuck's new show to a local paper: "It will feature local people and local activities. It will give attention, for instance, to the storefront organizations that are concerned with alcoholics, drug users, and other 'lost' segments of the community." Page five of the article showed a smiling Chubbuck posed with an ABC camera.
Chubbuck took her position seriously, inviting local Sarasota-Bradenton officials to discuss matters of interest to the growing beach community. After her death, the Sarasota Herald-Tribune reported that Chubbuck had been nominated for a Forestry and Conservation Recognition Award by the Bradenton district office of the Florida Division of Forestry. She was considered a "strong contender" by Mike Keel, district forester, who had been scheduled to appear as a guest on Ms. Chubbuck's show the morning of her suicide, but had cancelled because of the birth of his son.
Her focus on her lack of relationships was generally considered to be the driving force for her depression; her mother later summarized that "her suicide was simply because her personal life was not enough". She lamented to co-workers that her 30th birthday was approaching and she was still a virgin who had never been on more than two dates with a man. Her brother Greg later recalled several times she had gone out with a man, before moving to Sarasota, but agreed that she had trouble connecting socially in the beach resort town. He believed that her constant self-deprecation for being "dateless" contributed to her ongoing depression.
She had had her right ovary removed in an operation the year before, and had been told that if she did not become pregnant within a year, it was unlikely she would ever be able to conceive.
Apparently, she had an unrequited crush on co-worker George Peter Ryan. She baked him a cake for his birthday and sought his romantic attention, only to find out that he was already involved with sports reporter Andrea Kirby. Kirby had been the co-worker closest to Chubbuck, but was offered a new job in Baltimore, which had further depressed Chubbuck.
Chubbuck's lack of a romantic partner was considered a tangent of her desperate need to have close friends, though co-workers said that she tended to be brusque and defensive whenever they made friendly gestures towards her. She was self-deprecating, criticizing herself constantly and rejecting any compliments she was given. She was fond of word play and puns.
A week before her suicide she told Rob Smith, the night news editor, that she had bought a gun and joked about killing herself on air. Smith later told the Washington Post that he had chided her for the comment.
On July 12, 1974, she had an argument with news director Mike Simmons after he cut one of her stories to cover a shoot-out instead. Robert Nelson, the station owner, had tried to convince staff to concentrate on "blood and guts".
During the first eight minutes of her program, Chubbuck covered three national news stories and then a local restaurant shooting from the day before. The restaurant was the Beef and Bottle Restaurant at the Sarasota-Bradenton Airport on U.S. 41. The filmreel of the restaurant shooting had jammed and would not run, so Chubbuck shrugged it off and said:
"In keeping with Channel 40's policy of bringing you the latest in blood and guts, and in living color, you are going to see another first — attempted suicide."
She drew out the revolver and shot herself behind her right ear. Chubbuck fell forward violently and the technical director faded slowly to black. Camerawoman Jean Reed later recalled that she thought it had been an elaborate prank, and that it was not until she saw Chubbuck's twitching body that she realized it was genuine.
The station quickly ran a standard public service announcement and then a movie. Some television viewers called the police, while others called the station to inquire if the shooting was faked. After the shooting, news director Mike Simmons found that the papers from which Chubbuck had been reading her newscast contained a complete script of her program, including not only the shooting, but also a third-person account to be read by whatever staff member took over the broadcast after the incident. He said that her script called for her condition to be listed as "critical."
Chubbuck was taken to Sarasota Memorial Hospital, as her script had predicted; there, she was pronounced dead 14 hours later. Upon receiving the news, a WXLT staffer released the information to other stations using Chubbuck's script.
For a time, WXLT aired reruns of the TV series Gentle Ben in place of Chubbuck's program.
Presbyterian minister Thomas Beason delivered the eulogy, stating that "We suffer at our sense of loss, we are frightened by her rage, we are guilty in the face of her rejection, we are hurt by her choice of isolation and we are confused by her message."
All three national commercial television networks reported her death.
Christine's family brought an injunction against WXLT to prevent the release of the 2" quad videotape of her suicide. The Sarasota Sheriff's Department file lists a copy of the tape seized as evidence and later released it to Christine's family along with her possessions.
For the first time since 1974, Greg Chubbuck spoke publicly about his sister in a 2007 E! Entertainment Television special.