Garve became well-known particularly for his intensive activity as a translator (producing versions of, e.g., Cicero's De officiis and Adam Smith's Wealth of Nations). He composed psychological, moral and economic texts and reviews for the Neue Bibliothek der schönen Wissenschaften und der freyen Künste ("New Library of the Beautiful Sciences and Free Arts"). He was strongly marked by the influence of the English and Scottish Enlightenment as well as Stoic ethics. He never formulated his essentially empirical philosophy in terms of a system, publishing his thought in the form of remarks and essays. As a result he was reproached for being merely a shallow Popularphilosoph (popular philosopher), a reputation he has retained.
Of interest is his engagement with Immanuel Kant, which was initiated by a review of Kant's Critique of Pure Reason in the Göttinger Gelehrten Anzeigen ("Göttingen Learned Advertiser") which had been shortened by the Göttingen philosopher Johann Georg Heinrich Feder. Kant felt himself to have been misunderstood. When the original, longer review was published by Garve in the Allgemeine Deutsche Bibliothek ("General German Library"), it still attracted Kant's censure. Kant consequently wrote his own Anti-Garve. This program in time expanded into Kant's Prolegomena to Any Future Metaphysics That Will Be Able to Present Itself as a Science. The intellectual engagement between Kant and Garve extended up to Garve's death in 1798.