Khalil is best known for her role as the first actress to portray Lily Winters on the CBS soap opera The Young and the Restless. She played the role from August 15, 2002 until September 2, 2005. Soon after she left the soap, Khalil was replaced by Davetta Sherwood. Sherwood was let go seven months later by Lynn Marie Latham in favor of Khalil, who officially returned to the show on November 7, 2006.
Khalil had small roles in movies such as Dragon Fury, Matilda, Interview With the Assassin and White Like the Moon. She also voices Cornelia Hale in W.I.T.C.H. and also appeared on That's So Raven and Malcolm in the Middle among other shows. She is close friends with Desperate Housewives star, Lyndsy Fonseca.