He was involved in a questionable doctor stoppage bout with Thiago Alves on November 17, 2007. Alves was given the win with both fighters commenting that the fight should have continued.
Lytle fought Jasson Gilliam at UFC 73 on July 7, 2007. Lytle controlled the pace of the fight in the first round and eventually brought Gilliam to the ground. Lytle worked from top position, and eventually sunk in an inverted triangle choke from top position. To seal the fight he locked in an inverted armbar on Gilliam's free arm forcing him to tap.
At a United Fight League show which took place Indianapolis, Indiana on August 11, 2007 Lytle defeated Matt Brown by guillotine choke in the second round.
After losing to Thiago Alves at UFC 78: Validation via a highly controversial doctor stoppage due to a cut at the end of the second round, Lytle went on to defeat Kyle Bradley at UFC 81: Breaking Point by KO at 33 seconds of the first round. In an interview after the fight, Lytle stated that he had a new outlook on fighting; he would no longer pursue an "overly-technical" approach to each fight, but would go into his next fight and "not be afraid to lose."
On July 5, 2008 at UFC 86 Lytle lost to Josh Koscheck in a UFC Welterweight title eliminator fight. Kosheck used a brutal ground and pound style to open up massive cuts on Lytle's face. Lytle was bleeding profuseley but refused to give up losing via decision.
Lytle's next fight will be against British fighter Paul Taylor at UFC 89: Bisping vs. Leben on October 18th, 2008 in Birmingham, England.
| Result | Record | Opponent | Method | Event | Date | Round | Time | Location | Notes |
|---|---|---|---|---|---|---|---|---|---|
| Loss | 25-16-5 | Josh Koscheck | Decision (Unaiminious) | UFC 86: Jackson vs. Griffin | 3 | 5:00 | Nevada, United States | ||
| Win | 25-15-5 | Kyle Bradley | TKO (Strikes) | UFC 81 - Breaking Point | 1 | 0:33 | Nevada, United States | Won Knockout of the Night honors | |
| Loss | 24-15-5 | Thiago Alves | TKO (Doctor Stoppage - Cut) | UFC 78 - Validation | 2 | 5:00 | Prudential Center, Newark, NJ | Won Fight of the Night honors | |
| Win | 24-14-5 | Matt Brown | Submission (Guillotine Choke) | UFL - United Fight League | 2 | 2:49 | Indiana, United States | Won Submission of the Night honors | |
| Win | 23-14-5 | Jason Gilliam | Submission (Armlock) | UFC 73 - Stacked | 1 | 2:15 | ARCO Arena, Sacramento, Calif. | Won Submission of the Night Honors | |
| Loss | 22-14-5 | Matt Hughes | Decision (Unanimous) | UFC 68 - Uprising | 3 | 5:00 | Ohio, United States | ||
| Loss | 22-13-5 | Matt Serra | Decision (Split) | The Ultimate Fighter 4 Finale | 3 | 5:00 | Nevada, United States | ||
| Win | 22-12-5 | Ross Mason | Submission (Rear Naked Choke) | CR 15 - Adrenalin Rush | 2 | 4:57 | London, England | Cage Rage -77kg Title | |
| Win | 21-12-5 | Savant Young | Submission (Strikes) | WEC 18 - Unfinished Business | 1 | 3:50 | California, United States | ||
| Loss | 20-12-5 | Joe Riggs | TKO (Cut) | UFC 55 - Fury | 2 | 2:00 | Connecticut, United States | ||
| Win | 20-11-5 | Brian Dunn | TKO | LOF 1 - Legends of Fighting 1 | 1 | Indiana, United States | |||
| Win | 19-11-5 | Pat Healy | Decision (Split) | WEC 15 - Judgment Day | 3 | 5:00 | California, United States | ||
| Loss | 18-11-5 | Karo Parisyan | Decision (Unanimous) | UFC 51 - Super Saturday | 3 | 5:00 | Nevada, United States | ||
| Win | 18-10-5 | Jesse Taylor | Submission (Choke) | WEC 12 - Halloween Fury 3 | 1 | 2:53 | California, United States | ||
| Win | 17-10-5 | Ronald Jhun | Submission (Guillotine Choke) | UFC 49 - Unfinished Business | 2 | 1:17 | Nevada, United States | ||
| Win | 16-10-5 | Tiki Ghosn | Submission (Bulldog Choke) | UFC 47 - It's On | 2 | 1:55 | Nevada, United States | ||
| Win | 15-10-5 | Pete Spratt | Submission (Rear Naked Choke) | RSF - Shooto Challenge 2 | 1 | 0:46 | Illinois, United States | ||
| Loss | 14-10-5 | Robbie Lawler | Decision (Unanimous) | UFC 45 - Revolution | 3 | 5:00 | Mohegan Sun Casino Uncasville, Connecticut | ||
| Win | 14-9-5 | Derrick Noble | Submission (Rear Naked Choke) | RSF - Shooto Challenge | 2 | 2:04 | Illinois, United States | ||
| Win | 13-9-5 | Chatt Lavender | TKO (Triangle Choke) | AFC 5 - Absolute Fighting Championships 5 | 1 | 0:55 | Florida, United States | ||
| Win | 12-9-5 | LaVerne Clark | Decision (Unanimous) | Battleground 1 - War Cry | 3 | 5:00 | Illinois, United States | ||
| Loss | 11-9-5 | Koji Oishi | Decision (Split) | Pancrase - Hybrid 4 | 3 | 5:00 | Tokyo, Japan | ||
| Win | 11-8-5 | Aaron Riley | KO | HOOKnSHOOT - Boot Camp 1.1 | 1 | Indiana, United States | |||
| Loss | 10-8-5 | Izuru Takeuchi | Decision (Majority) | Pancrase - Spirit 9 | 3 | 5:00 | Tokyo, Japan | ||
| Win | 10-7-5 | Yuji Hoshino | Submission (Triangle Choke) | Pancrase - Spirit 7 | 1 | 2:09 | Tokyo, Japan | ||
| Loss | 9-7-5 | Nick Diaz | Decision | IFC WC 17 - Warriors Challenge 17 | 3 | 5:00 | California, United States | ||
| Win | 9-6-5 | Kazuo Misaki | Decision (Unanimous) | Pancrase - Proof 7 | 3 | 5:00 | Yokohama, Japan | ||
| Win | 8-6-5 | Jake Ambrose | Submission | CR 2 - Cage Rage 2 | 1 | Indiana, United States | |||
| Draw | 7-6-5 | Dave Strasser | Draw | RSF 3 - Reality Submission Fighting 3 | 1 | 18:00 | Illinois, United States | ||
| Draw | 7-6-4 | Nick Hide | Draw | CCC - Circle City Challenge | N/A | Indiana, United States | |||
| Win | 7-6-3 | Beaver Beaver | N/A | BBC - Bad Boy Competition | 1 | ||||
| Win | 6-6-3 | Mike Haltom | Submission (Strikes) | BBC - Bad Boy Competition | N/A | ||||
| Loss | 5-6-3 | Ben Earwood | Decision | UFC 28 - High Stakes | 2 | 5:00 | New Jersey, United States | ||
| Loss | 5-5-3 | Shonie Carter | Decision (Unanimous) | Pancrase - 2000 Anniversary Show | 3 | 3:00 | Yokohama, Japan | ||
| Win | 5-4-3 | Taro Obata | Submission (Arm Triangle Choke) | Pancrase - Trans 5 | 1 | 2:56 | Tokyo, Japan | ||
| Loss | 4-4-3 | Daisuke Ishii | Decision (Unanimous) | Pancrase - Trans 4 | 1 | 10:00 | Tokyo, Japan | ||
| Win | 4-3-3 | CJ Fernandes | Submission (Triangle Choke) | HOOKnSHOOT - Double Fury 1 | N/A | ||||
| Loss | 3-3-3 | Keiichiro Yamamiya | Decision (Unanimous) | Pancrase - Trans 1 | 1 | 10:00 | Tokyo, Japan | ||
| Draw | 3-2-3 | Ikuhisa Minowa | Draw | Pancrase - Breakthrough 11 | 1 | 15:00 | Yokohama, Japan | ||
| Loss | 3-2-2 | Dave Menne | Decision (Unanimous) | EC 29 - Extreme Challenge 29 | 2 | 5:00 | Wisconsin, United States | ||
| Win | 3-1-2 | Luke Pedigo | Submission (Guillotine Choke) | HOOKnSHOOT - Millennium | 1 | 1:57 | |||
| Draw | 2-1-2 | Takafumi Ito | Draw | Pancrase - 1999 Neo-Blood Tournament, Round 1 | 2 | 3:00 | Tokyo, Japan | ||
| Loss | 2-1-1 | Jason Delucia | Decision (Majority) | Pancrase - Breakthrough 7 | 1 | 10:00 | Tokyo, Japan | ||
| Win | 2-0-1 | Daisuke Watanabe | Submission | Pancrase - Breakthrough 6 | 1 | 5:30 | Tokyo, Japan | ||
| Draw | 1-0-1 | Osami Shibuya | Draw | Pancrase - Breakthrough 4 | 1 | 15:00 | Yokohama, Japan | ||
| Win | 1-0 | Bo Hershberger | Submission (Strikes) | NG 10 - Neutral Grounds 10 | 1 | 11:33 | Indiana, United States | ||