Charlotte of Bourbon (1546/1547 - Antwerp, 5 May 1582) was the daughter of Louis III de Bourbon, Duke of Montpensier and Jacqueline of Longwy. She was third spouse of William the Silent, the main leader of the Dutch revolt against the Spanish.
The couple married on 12 June, 1575 and had six daughters. Charlotte died from exhaustion while trying to nurse her husband after an assassination attempt in 1582.