The show premiered on September 30, 1991. It is presented by WNET, where it first aired as a local program.
Funding for the show is primarily provided by donations from various corporations and charitable foundations.
In 2007, the video archive of past interviews has been added to the website for free viewing. In a partnership with Google, nearly 4000 hours of video has also been added to YouTube featuring complete hour-long episodes as they originally aired.
Charlie Rose suffered shortness of breath while in Syria to interview President Assad in March, 2006. He was flown to Paris, where he was scheduled to undergo cardiac mitral valve repair. Rose returned on June 12, 2006 with Bill Moyers and Yvette Vega (the show's executive producer) and discussed Rose's surgery and recuperation.
There have been hundreds of guests on the show. Guest hosts have included: