With Benatar he was usually billed as Charlie Giordano and played for five albums, beginning in 1983; his role in the band was praised by Billboard magazine. With Benatar he was identifiable by his glasses and distinctive array of berets, blazers and 1980s-style ties. Giordano also was a member of The David Johansen Group and went on to perform with Buster Poindexter and The Banshees of Blue.
As a session musician Giordano's playing has included Madeleine Peyroux's 1996 album Dreamland and Bucky Pizzarelli's 2000 album Italian Intermezzo; the latter's mix of opera, Italian folk, and swing presaged his appearance in the similarly genre-mashing Sessions Band Tour with Springsteen. Giordano also participated in a 2002 revival of garage rock icons ? and the Mysterians. In 2008, he accompanied British singer Barb Jungr for a short stand in a New York City cabaret.