Beaumont was an outgoing, spontaneous person, prone to taking trips out of the country at a moment's notice. An avid racing fan, he would often enjoy participating in or watching area speedway races with other authors tagging along.
Beaumont wrote the scripts for some of the Twilight Zone series' most memorable episodes, including an adaptation of his own short story, "The Howling Man", the filming of which starred John Carradine. Playboy published his short story, "The Crooked Man", an early (1955) portrayal of homosexuality in speculative fiction. He famously scripted the Queen of Outer Space from an outline by Ben Hecht, deliberately writing the screenplay as a parody.
Posthumously much admired and appreciated by colleagues such as Ray Bradbury and Harlan Ellison, his work has been rediscovered in recent years with three collections of short stories published: Best of Beaumont (Bantam, 1982), Charles Beaumont: Selected Stories (Dark Harvest, 1988) and A Touch of the Creature (Subterranean Press, 1999). In 2004, Gauntlet Press released the first of what will be two volumes collecting Beaumont's Twilight Zone scripts.
"He was never well," his friend and colleague William F. Nolan would later recall.. "He was always thin. He almost always had a headache. He used Bromo-Seltzer like somebody would use water." George Clayton Johnson, his friend and fellow Twilight Zone writer, noted in his Archive of American Television interview that Beaumont's physical ailments stemmed from an extremely lengthy addiction to Bromo Seltzer.
Many of his friends and fellow writers, including Nolan and Jerry Sohl, took to ghostwriting for Beaumont so that he could fulfill his many writing commissions, despite his illness. Privately, he insisted on splitting his fees with those authors who wrote the pieces for him. He died in Woodland Hills, California at the age of 38. Beaumont's last residence was in nearby Valley Village, California.