The town's name is derived from the Slavic (more precisely Bulgarian) černa voda (черна вода in Cyrillic), meaning "black water". This name is a calque of the earlier Thracian name Axíopa, from IE *n.ksei "dark" and upā "water" (cf. Avestan axšaēna "dark" and Lithuanian ùpė "river, creek") .
The Danube-Black Sea Canal, opened in 1984, runs from Cernavodă to Agigea and Năvodari.
The outskirts of Cernavodă host numerous vineyards, producers of Chardonnay wine. The largest winery in the area is Murfatlar.
Cernavodă was founded (under the name Axiopolis) by the ancient Greeks in the 4th century BC as a trading post for contacts with local Dacians.
The Constanţa - Cernavodă railroad was opened in 1860 by the Ottoman administration.
In 1895, the King Carol I Bridge was built across the Danube.
The town gives its name to the late copper age Cernavodă archaeological culture, ca. 4000—3200 BC.