The facade is interesting in that it involves the use of solomonic columns which were not widely used in New Spain at the time. It has an octagonal window that was shipped from Germany and is considered a fine specimen of the glassmakers art. In addition, the front contains a collection of monuments celebrating the twelve apostles, with a clock above, crowned with the sculpture of an angel that was added in the 19th century. The royal Spanish coat of arms occupied the area below the angel, but was removed by Architect José Félix Maceira in 1874 and the clock, which was acquired in London, was added, giving the facade its present appearance.
The nave is divided from the ambulatories by arches which support the massive ceiling, and has a fine baptistry chapel on the right, or north side, just inside from the narthex. Directly opposite, on the south side, inside the Chapel of Christ of Mapimí, is the tomb of St Peter of Jesus Maldonado, a priest and martyr who was ordained in the Cathedral Parish of Saint Patrick in El Paso, TX and canonised by Pope John Paul II in 2000. The chapel is decorated with an 18th century retablo, or reredos containing a venerated image of Christ, in which Primitive and Baroque elements are mingled. The chancel contains an unusual double altar, in which a smaller altar of Carrara marble was incorporated into the existing larger one, of local quarry stone, after the church was built. The organ in the east gallery was built in 1885 by Hook and Hastings, Op. 1244 (2 manuals, 18 registers), and rebuilt and expanded by E F Walcker & Cie. in 1960. The Hook and Hastings instrument had, in turn, replaced a George Jardine organ that was built in 1837, and rebuilt by Jardine in 1869.
The Blessed Sacrament Chapel, of baroque and rococo design, is reached by a door in the south side of the nave. The Sacred Art Museum is located in the crypt. It displays a collection of paintings by such artists as Cabrera, José de Alcíbar and Antonio de Torres, as well as communion plate and other pieces from the Colonial era.
The first stone was placed on June 21 1725 by the Bishop of Nueva Vizcaya in Durango, Don Benito Crespo y Monroy (It must be remembered that, in those times, Chihuahua depended religiously upon, and was a part of, the Diocese of Durango.) The church was paid for with local commercial donations and by mine owners in the city and in Santa Eulalia, a pueblo to the east, and also by a tax of one real on each mark of silver that was mined in the province.
The first superintendent of construction was Pedro Coronado, followed by Miguel de la Sierra and then Master Architect José de la Cruz, who finalised the plans, and was buried in the church upon his death in 1734. Others followed until Architect Bernardo del Carpio began the construction of the towers in 1758. The bells had been cast in 1730, and were placed in the newly-completed towers in 1780, directed by Superintendent Melchor Guaspe.
Construction of the church was completed in 1826. The building was slightly damaged during the French invasion, repaired, and was designated a cathedral on 23 June, 1891 with the erection of the Chihuahua diocese from the Diocese of Durango. At that time, the new diocese was responsible for the faithful throughout the entire state. Chihuahua was elevated to the status of an archdiocese on 22 November, 1958 and now is the metropolitan archdiocese for five suffragan dioceses in the state of Chihuahua.
In 1910 with the commemoration of the Century of Independence of Mexico, the cathedral was decorated with lights. It wasn't until 2005 when the cathedral was illuminated again, this time permanently.