Cacamatzin was a 15th century Aztec noble — the eldest son of the cihuacoatl, Tlacaelel — and warrior who held the title of Tlacochcalcatl.

He had twelve children, only three of whom are known:

• A female (name unknown), who married Nezahualpilli, the tlatoani of Texcoco. The pair had a son, named Cacamatzin after his grandfather, who succeeded his father as ruler of Texcoco.
• Tlacaelel, named after his grandfather, who also became cihuacoatl.
• Chicuey or Chicome Axochitzin, a warrior whose daughter became the mistress of Juan Rodríguez de Villafuerte, a Spanish conquistador.

Cacamatzin was killed by the Tarascans after being captured in battle.

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