Borromini's first major independent commission was the reconstruction in 1634-37 of the interior spaces of the church and adjacent buildings of San Carlo alle Quattro Fontane (also called San Carlino); the façade of the small church would be completed by Borromini much later, at the end of his career, which San Carlo neatly brackets. The church is dedicated to San Carlo Borromeo, and may have prompted his name change. The small church is considered by many an iconic masterpiece of Roman Baroque. Borromini avoided linear classicism and eschewed a simple circular shape in favor of a corrugated oval, beneath an oval dome that is coffered in a system of crosses and octagons that diminishes towards the lantern, source of all the light in this dark interior The church is small; its complex convex-concave rhythms disrupt the oval of the nave; he "designed the walls to weave in and out as if they were formed not of stone but of pliant substance set in motion by an energetic space, carrying with them the deep entablatures, the cornices, moldings and pediments" (Trachtenberg & Hyman). It is far bolder in geometric intricacy and less encrusted with figurative decorations than Bernini's Sant'Andrea al Quirinale, which lies just down the street. That latter church has a sculptural drama embedded into the architecture, as a form of bel composto. In San Carlino, the drama is rational and geometric. The undulating elements in the façade (1662-67; illustration, right), united by a serpentining cornice, and sculpted with niches, are also masterful; such flexing boldness bore fruit especially in the distinctive Neapolitan and Sicilian Baroque.
Borromini lost this commission before completion due to the death of the Pope Innocent X in 1655. The new Pope, Alexander VII, and Prince Camillo Pamphilj recalled Rainaldi, but this one didn't change very much and the church is mainly considered a notable expression of Borromini's concepts.
The congregation of the Filippini already had one of the most well-decorated Baroque churches in Rome, and the order, so enthralled by the piousness encouraged by music, had planned to build an oratory, as well as a residential quarters, adjacent to the church of Santa Maria in Vallicella (Chiesa Nuova) located in crowded central Rome. Borromini won a competition for designing the structure against many including Paolo Maruscelli. He was employed in the task for 13 years, often a testy process. By 1640, the oratory was in use, by 1643, the library was complete. The striking facade adjacent to the church entrance has little regard for the structures behind. Inside the oratory is articulated by half columns and a complex rhythm of pilasters.
Borromini was a contemporary with the prolific papal architect, and specially late in life, a rival of the eminently successful Gian Lorenzo Bernini. Borromini is purported to be a strong influence on the Piedmontese architect, Camillo-Guarino Guarini and his successors.
The primary inscription on Borromini's tomb, in San Giovanni dei Fiorentini, reads:
FRANCISCVS BORROMINI TICINENSIS
EQVES CHRISTI
QVI
IMPERITVRAE MEMORIAE ARCHITECTVS
DIVINAM ARTIS SVAE VIM
AD ROMAM MAGNIFICIS AEDIFICIIS EXORNANDAM VERTIT
IN QVIBUS
ORATORIVM PHILLIPINVM S. IVO S. AGNES IN AGONE
INSTAVRATA LATERANENSIS ARCHIBASILICA
S. ANDREAS DELLE FRATTE NVNCVPATUM
S. CAROLVS IN QVIRINALI
AEDES DE PROPADANDA FIDE
HOC AVTEM IPSVM TEMPLVM
ARA MAXIMA DECORAVIT
NON LONGE AB HOC LAPIDE
PROPE MORTALES CAROLI MADERNI EXUVVIAS
PROPINQVI MVNICIPIS ET AEMVLI SVI
IN PACE DOMINI QVIESCIT
Francesco Borromini was featured on the 100 Swiss Franc banknote current in the 1980s .