Beta-1_adrenergic_receptor

Beta-1 adrenergic receptor

The beta-1 adrenergic receptor1 adrenoreceptor), also known as ADRB1, is an beta-adrenergic receptor, and also denotes the human gene encoding it.

Receptor

Actions

Actions of the β1 receptor include:

Agonists

Isoprenaline has higher affinity for β1 than noradrenaline, which, in turn, binds with higher affinity than adrenaline. Selective agonists to the beta-1 receptor are:

Antagonists

(Beta blockers) β1-selective ones are:

Mechanism

Gs renders adenylate cyclase activated, resulting in increase of cAMP.

Gene

Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure.

See also

References

Further reading

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