She led the vocal group Bea and the Bachelors (with Al Rinker, Ken Lane, and John Smedberg), and the V8 (seven boys and a girl) on the Fred Waring show. In 1937, Wain joined former Tommy Dorsey arranger Larry Clinton and His Orchestra. She was featured with Clinton on a number of hit tunes, including "Martha" and "Heart and Soul". In 1939, she was voted the most popular female band vocalist in a Billboard poll. She began her solo career in 1939 with a number of hit songs, including "Deep Purple" and "My Reverie."
Wain is considered by many to be one of the best female vocalists of her era, possessing a natural feel for swing-music rhythms not often found among white singers of the day. With regard to technique, she excelled in pitch and subtle utilization of dynamics. She also communicated a feminine sensuality and sang with conviction in an unforced manner.
On May 1, 1938, Bea Wain married veteran radio announcer André Baruch. Their honeymoon in Bermuda was cut short when Fred Allen called Baruch asking him to return to New York to substitute for his ailing announcer, Harry von Zell. They were married for 53 years. Baruch died in 1991.
In a 2004 interview with Christopher Popa, she reflected:
In James A. Michener's 1971 novel The Drifters, characters discuss Bea Wain and her recording of "My Reverie". In 2002, her recording of "My Reverie" was used in the Robin Williams movie One Hour Photo.
The couple had two children: Bonnie Baruch and her husband, Mark Barnes, operate a vineyard in Northern California and run the Daisy Foundation, an organization which recognizes nurses for their critical role in patient care and supports research towards the cure of auto-immune diseases. Wayne Baruch has a career in the music and theatre business, and his wife, Shelley Baruch, is a theatrical producer and filmmaker.