After being introduced to DJ Muggs by Julio G the KDAY Mixmaster, B-Real and Sen gained interest in Muggs' concept of an album based on experiences from Cypress Ave in South Gate. The group was signed with Ruffhouse/Columbia records in 1991, and made their influential debut that year. B-Real would use his life-threatening experiences as material for the group's self-titled debut album, and subsequent releases.
Cypress Hill's trademark sound - an eccentric combination of B-Real's exaggeratedly high-pitched nasal vocals and DJ Muggs' distinctive beats - led to the trio becoming the first Latin rap group to have Platinum and Multi-Platinum albums. They remain the best selling Latin rap group to date.
Aside from Cypress Hill, B-Real has been involved in several other musical projects. In 1996 he contributed to the soundtrack for the movie Space Jam. In 2002, he teamed up with Mellow Man Ace and Son Doobie for the short-lived Serial Rhyme Killas, which released one 12" single in 2002. The group recorded a full-length debut album, entitled Deluxe Rapture, but it was never released. He was also previously a member of the group The Psycho Realm.