Asosa is bordered on the south by the Mao-Komo special woreda, on the west by Sudan, on the northeast by the Abay River which separates it from Metekel, and on the east by the Dabus River which separates it from Kamashi. The largest town in this zone is Asosa. Its highest point is Mount Bambasi, located in the woreda of the same name.
According to a May 24, 2004 World Bank memorandum, 9% of the inhabitants of Asosa have access to electricity, this zone has a road density of 35.6 kilometers per 1000 square kilometers, the average rural household has 1 hectare of land (compared to the national average of 1.01 hectare of land and an average of 2.25 for pastoral Regions) and the equivalent of 0.4 heads of livestock. 17.1% of the population is in non-farm related jobs, compared to the national average of 25% and a regional average of 28%. 72% of all eligible children are enrolled in primary school, and 13% in secondary schools. 34% of the zone is exposed to malaria, and 58% to Tsetse fly. The memorandum gave this zone a drought risk rating of 324.