In 1922, Gorky enrolled in the New School of Design in Boston, eventually becoming a part-time instructor. During the early 1920s he was influenced by impressionism, although later in the decade he produced works that were more postimpressionist. During this time he was living in New York and was influenced by Paul Cezanne. In 1927, Gorky met Ethel Kremer Schwabacher and developed a life lasting friendship. Schwabacher was his first biographer.
Notable paintings from this time include Landscape in the Manner of Cézanne (1927) and Landscape, Staten Island (1927 - 1928). At the close of the 1920s and into the 1930s he experimented with cubism, eventually moving to surrealism. Nighttime, Enigma, Nostalgia (1930-1934) is a series of complex works that characterize this phase of his painting. The canvas below Portrait of Master Bill depicts Gorky's friend, Willem de Kooning.
In English translations of letters allegedly written by Gorky in Armenian to his sisters he often described moods of melancholy, and expressed loneliness and emptiness, nostalgia for his country, and bitterly and vividly recalled the circumstances of his mother's death. Most of these translations (especially those expressing nationalistic sentiments or imparting specific meanings to his paintings) are now considered to be fakes produced by Karlen Mooradian (a nephew of Gorky) in the late 1960s and early 1970s. Unfortunately, the contents of the fake letters heavily influenced the authors of books written about Gorky and his art during the 1970s and 80s.
Gorky's later years were filled with immense pain and heartbreak. His studio barn burned down, he underwent a colostomy for cancer, his neck was broken and his painting arm temporarily paralyzed in a car accident, and his wife of seven years left him, taking their children with her. Gorky hanged himself in Sherman, Connecticut, in 1948, at the age of 44. He is buried in North Cemetery in Sherman, Connecticut.
His daughter, the painter Maro Gorky, married Matthew Spender, son of the British writer Sir Stephen Spender.
Gorky's contributions to American and world art are difficult to overestimate. The painterly spontaneity of mature works like "The Liver is the Cock's Comb," "The Betrothal II," and "One Year the Milkweed" immediately prefigured Abstract expressionism, and leaders in the New York School have acknowledged Gorky's considerable influence. But his oeuvre is a phenomenal achievement in its own right, synthesizing Surrealism and the sensuous color and painterliness of the School of Paris with his own highly personal formal vocabulary. His paintings and drawings hang in every major American museum including the National Gallery of Art, the Museum of Modern Art, the Metropolitan and the Whitney Museum of American Art in New York (which maintains the Gorky Archive), and in many worldwide, including the Tate in London.
Gorky appears as a character in Charles L. Mee's play about Joseph Cornell, Hotel Cassiopeia. and is briefly mentioned in Kurt Vonnegut's novel "Bluebeard".
Stephen Watts's poem 'The Verb "To Be"' (Gramsci&Caruso, Periplum 2003) is dedicated to Gorky's memory.