Antrel Rolle attended South Dade High School in Homestead, Florida. As a senior, on defense, he posted three interceptions and 86 tackles. On offense, he had four receptions for 160 yards (40.0 yards per rec. avg.) and a touchdown. As a junior, on defense, he posted three interceptions, 85 tackles, and five pass deflections, and he returned three kickoffs and three punts for touchdowns. San francisco 49ers free safety marcus hudson high school teammate.
In 2001, his freshman season, Rolle was one of four true freshman to letter at Miami. He appeared in eight games, recording eight tackles and an interception. Rolle started 11 games as a sophomore in 2002, earning All-Big East first-team honors. Rolle totaled a career-high 66 tackles with two sacks, six tackles for a loss, seven pass deflections, and an interception for the season.
In 2003, as a junior, Rolle recorded 51 tackles, 3.5 tackles for a loss, seven broken up passes, and two interceptions on the year. In his final season, 2004, Rolle was a consensus All-American. He recorded 58 tackles his senior year, 6.5 tackles behind the line of scrimmage, six pass deflections, and an interception. He was hurt late in the '04 season and missed the Virginia Tech game due to a foot sprain.
Rolle's career did not start off well mainly because of torn cartilage in his left knee suffered September 25, 2005 in a game against the Seattle Seahawks. The torn cartilage required surgery on October 3, 2005 and put Rolle out for almost the entire 2005 NFL season.
Rolle returned and played on December 11, 2005 against the Washington Redskins, where he recorded his first interception and returned it for 29 yards. He played in week 14 and again in week 15 against the Houston Texans.
The 2007 campaign did not start well for Rolle as he lost his starting spot in the preseason. However, he battled back and had the highlight of his career on November 18 when he intercepted 3 passes by Carson Palmer of the Cincinnati Bengals, returning the first two for touchdowns of 55 and 54 yards. He returned the third interception all the way to the end zone as well, but it was called back on a penalty. Rolle was rewarded for his performance when he was named NFC Defensive Player of the Week. Rolle finished the season with 61 tackles, 5 interceptions, and three return touchdowns. His interception total was tied for ninth most in the NFL. Cardinals Head Coach Ken Whisenhunt announced on February 2008 that Rolle will be moved to free safety for the 2008 season.