Amy Sedaris lives in Greenwich Village with her mini rex rabbit Dusty and is very involved with the House Rabbit Society. As part of a running joke during public appearances, she frequently alludes to her imaginary boyfriend, Ricky. During an appearance on the Late Show with David Letterman (October 6, 2006), she claimed Ricky had been murdered and she now lives with Ricky's ghost.
Sedaris also hosted the series Film Fanatic on Trio. She coauthored the text-and-picture novel Wigfield with Paul Dinello and Stephen Colbert, published in 2003. As of 2005, Sedaris writes a monthly advice column in The Believer. She has written a guide to entertaining titled I Like You: Hospitality Under the Influence, published in October 2006 by Warner Books. That light-hearted approach to cooking stayed on the New York Times best-sellers list for over 12 weeks, and currently has over 350,000 copies in print.
Along with her brother, author and essayist David Sedaris, Amy has co-authored several plays under the name "The Talent Family." These include: Stump the Host (1993), Stitches (1994), One Woman Shoe (1995), Incident at Cobblers Knob (1997) and The Little Frieda Mysteries (1997) which were all produced and presented by Meryl Vladimer, when she was the artistic director of "the CLUB" at La MaMa Experimental Theatre Club Incident at Kobblers Knob was presented and produced by David Rockwell at the Lincoln Center Festival. She co-authored the play The Book of Liz with her brother. She played the stage manager in Paul Rudnick's play The Most Fabulous Story Ever Told.
Sedaris appeared in two episodes of Rescue Me, two episodes of Monk, an episode of Wonder Showzen, on Just Shoot Me! as a female version of David Spade's character, and as Carrie Bradshaw's book publisher in Sex and the City. She also played Paulie the Penis in the online comedy sketch 'The Puberty Pals'. She guest-starred as Randy's cat-obsessed girlfriend in an October 2006 episode of My Name Is Earl. She has also made a guest appearance on Sesame Street as a flustered Snow White who keeps losing her dwarves.