Depending very much on the protocols used, the body may adapt to the relative lack of oxygen hypoxia in one or more of a number ways such as increasing the mass of red blood cells and hemoglobin, and non-hematolological responses . Proponents claim that when such athletes travel to competitions at lower altitudes they will still have a higher concentration of red blood cells for 10-14 days, and this gives them a competitive advantage. Some athletes live permanently at high altitude, only returning to sea level to compete, but their training may suffer due to less available oxygen for workouts.
Scientific studies have shown that altitude training can produce increases in speed, strength, endurance, and recovery. Opponents of altitude training argue that an athlete's red blood cell concentration returns to normal levels within days of returning to sea level and that it is impossible to train at the same intensity that one could at sea level, reducing the training effect and wasting training time due to altitude sickness. Altitude simulation systems have enabled protocols that do not suffer from such compromises, and can be utilized closer to competition if necessary. Some devices would be considered portable.
A 2005 study showed that although the boosted VO2 max had returned to normal 15 days after the conclusion of an 18-day Live High Train Low protocol, the submaximal performance at ventilatory threshold was enhanced upon initial return to sea-level, and was even greater 15 days later.
Numerous other responses to altitude training have also been identified, including angiogenesis, glucose transport, glycolysis, and pH regulation, each of which may partially explain improved endurance performance independent of a larger number of red blood cells.. Furthermore, exercising at altitude has been shown to cause muscular adjustments of selected gene transcripts., and improvement of mitochondrial properties in skeletal muscle.
In Finland, a scientist named Heikki Rusko has designed a "high-altitude house." The air inside the house, which is situated at sea level, is at normal pressure but modified to a low concentration of oxygen, about 15.3% (below the 20.9% at sea level), the same concentration as that at the altitudes often used for altitude training. Athletes live and sleep inside the house but perform their training outside (at normal oxygen concentrations at 20.9%). Rusko's results show improvements of EPO and red-cell levels. His technology has been commercialized and is being used by thousands of competitive athletes in cycling, triathlon, olympic endurance sports, professional football, basketball, hockey, soccer, and many other sports that can take advantage of the improvements in strength, speed, endurance, and recovery.