In 1713, he married Frances Thynne and had two children:
The Duke was one of the richest landowners in England, but as he died with no son his estates were split after his death. The ducal title passed to a distant cousin Edward Seymour, 8th Duke of Somerset. Most of the traditional Percy estates passed to his daughter and her husband (see Alnwick Castle, Northumberland House and Syon House). Petworth in Sussex passed to the duke's nephew Charles Wyndham, 2nd Earl of Egremont. Later dukes of Somerset lived at Maiden Bradley, a far more modest estate than those already mentioned.