Ganji has won several international awards for his work, including the World Association of Newspapers' Golden Pen of Freedom Award , Canadian Journalists for Free Expression's International Press Freedom Award, the Martin Ennals Award for Human Rights Defenders, and the John Humphrey Freedom Award.
In 1994-5 Ganji became disenchanted with the regime. "I saw a fascism and political tyranny emerging in Iran. Anyone who asked questions was branded `anti-revolutionary` and `against Iran`. He quit the Guard to become an investigative journalist. Shortly thereafter he gained fame and ran afoul of Islamic authorities by "exposing the role of high officials in sanctioning the murder of liberal dissidents."
In December 2000, after his arrest (see below), Akbar Ganji announced the "Master Key" to the chain murders was former Intelligence Minister Hojjatoleslam Ali Fallahian. He "also denounced by name some senior clerics, including Ayatollah Mohammad Taqi Mesbah-Yazdi for having encouraged or issued fatwas, or religious orders for the assassinations." Conservatives have attacked Ganji and denied his claim.
Collections of his articles appeared in books, notably, "The Dungeon of Ghosts" and "The Red Eminence, The Grey Eminences" focusing on the involvement of the former President of Iran, Akbar Hashemi Rafsanjani, and his Minister of Intelligence, Ali Fallahian, in the chain murders.
Ganji was on a hunger strike for more than 80 days from 19 May 2005 until early August 2005 except for a 12-day period of leave he was granted on May 30 2005 ahead of the ninth presidential elections on 17 June 2005. His hunger strike ended after 50 days when "doctors warned he would sustain irreparable brain damage, and he relented." Many Iranians had not heard of the hunger strike due to press censorship and heavy security and information quarantine in Milad hospital in Tehran. He is represented by a group of lawyers, including Dr. Yousef Molaei, Abdolfattah Soltani (who was arrested and put in solitary confinement in 2005 on unknown charges), and the 2003 Nobel Peace Prize Laureate, Shirin Ebadi. While on hunger strike Ganji wrote two letters to the free people of the world: .
On 12 July 2005 the White House press secretary Scott McClellan said in a statement that President George W. Bush called on Iran to release Ganji "immediately and unconditionally… Mr. Ganji is sadly only one victim of a wave of repression and human rights violations engaged in by the Iranian regime… His calls for freedom deserve to be heard. His valiant efforts should not go in vain. The president calls on all supporters of human rights and freedom, and the United Nations, to take up Ganji's case and the overall human rights situation in Iran… Mr. Ganji, please know that as you stand for your own liberty, America stands with you," the statement went on.
In his recent leave in June 2005, Ganji participated in interviews with several news agencies, criticizing Ayatollah Ali Khamenei, the Supreme Leader of Iran, and asking for his office to be put to public vote
This led to a ruling by Saeed Mortazavi, the general prosecutor of Tehran, to arrest him again because of "illegal interviews". He returned to prison voluntarily on June 11, 2005 and started another hunger strike.
Ganji was released from prison in poor health on 18 March 2006, after serving the full term of his six-year sentence, according to his family and various count-downs set up on many Iranian weblogs. At the same time, the deputy prosecutor of Tehran, Mahmoud Salarkia, claimed that 10 days remained from his sentence due to unaccounted days of absence, and that he had been granted a leave for the Persian New Year. The claim has apparently been dropped since.
Ganji's writings in prison were smuggled out and widely distributed, especially on the web. Most notably he wrote a Republican Manifesto in six chapters in March 2002, laying out the basis of his proposal for a fully-fledged democratic republic for Iran. In particular he argued that all elections in the Islamic Republic of Iran must be boycotted. He later wrote a second book of his Republican Manifesto in May 2005, ahead of the ninth Presidential elections in Iran, specifically arguing for a complete boycott of the presidential elections.
In April 2008, Ganji's first English language book appeared from Boston Review Books/MIT Press: The Road to Democracy in Iran, with an introduction by Joshua Cohen and Abbas Milani.
Ganji opposes the United States 2003 invasion of Iraq and subsequent occupation.
In 2006, Akbar Ganji started a tour to visit world leading philosophers, theorists, human rights activists. His goal has been said to be introducing Iranian intellectual movements and democratic circles to world leading thinkers. He met many famous figures as Richard Rorty, Noam Chomsky, Anthony Giddens, David Hild and Shmuel Noah Eisenstadt.
While in the United States in July 2006, Ganji declined an invitation to meet with White House officials, citing his belief that current US policies were not helping promote democracy in Iran. He was quoted as saying, "You cannot bring democracy to a country by attacking it". He also added that the war in Iraq was promoting Islamic fundamentalism and hurting movements towards democracy in the region.
Ganji declared that his role was as a dissident and journalist, rather than the official voice for a specific opposition party or faction within Iran, which he explained was one reason for his refusal to meet with US political leaders and officeholders.
During his visit he criticized the Iraq war, asserting that rather than undermining the current Iranian regime it had instead bolstered its capacity to repress and terrorize its population.
We do not want the regime of the Islamic Republic of Iran. However, this is our problem. Any intervention by any foreign power would bring charges of conspiracy against us... What has happened in Iraq did not support our movement in any significant way.''
He also staged a hunger strike outside of the United Nations headquarters in order to highlight the plight of Iranian political prisoners, and to bring international attention to the oppressive conditions felt within Iran.