An acetylcholinesterase inhibitor or anti-cholinesterase is a chemical that inhibits the cholinesterase enzyme from breaking down acetylcholine, so increasing both the level and duration of action of the neurotransmitter acetylcholine.
|Inhibitor||Duration||Main site of action||Clinical use||Adverse effects|
|Edrophonium||short (10 min.)||neuromuscular junction||diagnosis of myasthenia gravis|
|Neostigmine||medium (1-2 hrs.)||neuromuscular junction|
|Physiostigmine||medium (0.5-5 hrs.)||postganglionic parasympathetic||treat glaucoma (eye drops)|
|Pyridostigmine||medium (2-3 hrs.)||neuromuscular junction|
|Dyflos||long||postganglionic parasympathetic||historically to treat glaucoma (eye drops)||toxic|
|Ecothiopate||long||postganglionic parasympathetic||treat glaucoma (eye drops)||systemic effects|
Some major effects of anticholinesterase inhibitors:
Pipeline: highlights of progress in drug development.(acetylcholinesterase inhibitor development for Alzheimer's disease)(pleuromutilin antibiotic development for skin infections)(Sitagliptin phosphate development for type 2 diabetes)
Mar 01, 2006; CNS Dextromethorphan + quinidine (Neurodex, from Avanir) a combination product being developed for the treatment of involuntary...