The film was the last in a long working relationship between Winterbottom and screenwriter Frank Cottrell-Boyce. After some dispute, Boyce decided to take his name off the script, instead using the pseudonym 'Martin Hardy'.
The film incorporates several sequences from the film-within-the-film of Tristram Shandy; these are limited to the story of Tristram's conception, birth and christening; Uncle Toby's experiences at the Battle of Namur; Tristram's sudden and accidental circumcision at the age of three; and the concluding scene of the novel, in which Yorick says "It is a story about a Cock and a Bull - and the best of its kind that ever I heard!"
The film's soundtrack is notable for featuring numerous excerpts from Nino Rota's score for the Federico Fellini film 8 1/2, itself a self-reflexive work about the making of a film. Other non-diegetic musical references are made to Amarcord, The Draughtsman's Contract, Smiles of a Summer Night and Barry Lyndon. Michael Nyman, composer of The Draughtsman's Contract provides a new arrangement of the Handel Sarabande feautred in the latter film, while the pre-existing tracks of The Draughtsman's Contract (the original soundtrack recordings--the score has been rerecorded numerous times) serve as a temp track to film of the Sterne material.