MAP kinase kinase kinase

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MAP kinase kinase kinase (or MAP3K or MEKK) is a serine/threonine-specific protein kinase which acts upon MAP kinase kinase.

There are 15 genes:

• MAP3K1 (aka MEKK1)
• MAP3K2
• MAP3K3 (aka MEKK3)
• MAP3K4
• MAP3K5
• MAP3K6
• MAP3K7 (aka MEKK7)
• MAP3K8
• MAP3K9
• MAP3K10
• MAP3K11 (aka MEKK11)
• MAP3K12
• MAP3K13
• MAP3K14
• MAP3K15

MEKK1 activates MAPK8/JNK by phosphorylation of its activator SEK1(MAP2K4). MAP3K3 directly regulates the MAPK8/JNK and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. MAP3K7(TAK1)participate in regulation of transcription by transforming growth factor-beta (TGF-beta).

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Last updated on Thursday December 27, 2007 at 21:29:10 PST (GMT -0800)
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