ACES is the common abbreviation for the compound N-(2-Acetamido)-2-aminoethanesulfonic acid.
ACES is one of Good's buffers developed in the 1960's to provide buffers with pH ranging from 6.15-8.35 for use in various applications. With a pKa of 6.9, it is often used as a buffering agent in biological and biochemical research. It is a zwitterionic buffer with a useful buffering range of 6.1-7.5. The pioneering publication by Good and his co-workers described the synthesis and physical properties of ACES buffer.
ACES had been used to develop buffers for both agarose
and polyacrylamide gel electrophoresis
ACES use in isoelectric focusing
has also been documented. Use of ACES has been published in a protocol for the analysis of bacterial autolysins
in a discontinuos SDS-PAGE
system. Potential inhibition of ACES and other Good buffers
has been investigated in γ-aminobutyric acid receptor binding to rat brain synaptic membranes.
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