Following shakedown in the Atlantic and Caribbean, Silversides began operations in the Atlantic, homeported at Charleston, South Carolina.
The USS Silversides went into drydock in Norfolk Naval Shipyard in January 1977 and changed its home port to Norfolk, Virginia.
In the Fall of 1984, the Silversides left its Norfolk Naval Base homeport for its journey to a scheduled refueling-overhaul at Puget Sound Naval Shipyard, entering drydock there in late November 1984. The refueling-overhaul was completed by August 1986, and later that year the boat returned to her homeport of Norfolk, Virginia.
In Fall 1989 USS Silversides surfaced at the North Pole, proceeded out of the Arctic Ocean into the Pacific, participated in Pacific Fleet Exercises, made port calls in Hawaii and California and proceeded back to Norfolk through the Panama Canal, becoming only the second submarine to circumnavigate the North American continent. In mid 1994, she moved from her homeport in Norfolk to Pearl Harbor, Hawaii for decommissioning on 21 July 1994.
Silversides was stricken from the Naval Vessel Register on 2 August 1994. Ex-Silversides entered the Nuclear Powered Ship and Submarine Recycling Program in Bremerton, Washington, on 1 October 2000 and on 1 October 2001 ceased to exist.