The Pirates finished their season 7-5, 5-3 in the
C-USA:
| Date
| Opponent
| Location
| Result/Time
|
| 2 Sep 06
| Navy
| Annapolis, Maryland
| L, 23-28 |
| 9 Sep 06
| UAB
| Birmingham, Alabama
| L, 12-17 |
| 16 Sep 06
| Memphis
| Greenville, North Carolina
| W, 35-20 |
| 21 Sep 06
| (4)West Virginia
| Greenville, North Carolina
| L, 10-27 |
| 30 Sep 06
| Virginia
| Greenville, North Carolina
| W, 31-21 |
| 7 Oct 06
| Tulsa
| Greenville, North Carolina
| L, 10-31 |
| 14 Oct 06
| SMU
| Greenville, North Carolina
| W, 38-21 |
| 19 Oct 06
| Southern Miss
| Hattiesburg, Mississippi
| W, 20-17 |
| 28 Oct 06
| UCF
| Orlando, Florida
| W, 23-10 |
| 4 Nov 06
| Marshall
| Greenville, North Carolina
| W, 33-20 |
| 18 Nov 06
| Rice
| Houston, Texas
| L, 17-18 |
| 25 Nov 06
| NC State
| Raleigh, North Carolina
| W, 21-16 |
| 23 Dec 07
| South Florida (Papajohns.com Bowl)
| Birmingham, Alabama
| L, 7-24 |
| C-USA Games |
| Homecoming |
| Bowl Game |