Guitars have been constructed which use 15-ET tuning. The American musician Wendy Carlos used 15-ET as one of two scales in the track Afterlife from the album Tales of Heaven and Hell. Easley Blackwood Jr. has written and recorded a suite for 15-ET guitar.
Here are the sizes of some common intervals in 15-ET:
| interval name | size (steps) | size (cents) | just ratio | just (cents) | difference |
| perfect fifth | 9 | 720 | 3:2 | 701.96 | 18.04 |
| 11th harmonic | 7 | 560 | 11:8 | 551.32 | 8.68 |
| perfect fourth | 6 | 480 | 4:3 | 498.04 | -18.04 |
| major third | 5 | 400 | 5:4 | 386.31 | 13.69 |
| minor third | 4 | 320 | 6:5 | 315.64 | 4.36 |
| septimal whole tone | 3 | 240 | 8:7 | 231.17 | 8.83 |
| greater undecimal neutral second | 2 | 160 | 11:10 | 165.00 | -5.00 |
| undecimal minor semitone | 1 | 80 | 22:21 | 80.54 | -0.54 |
Although it contains a perfect fifth as well as major and minor thirds, the remainder of the harmonic and melodic language of 15-ET is quite different from 12-ET, and thus 15-ET could be described as xenharmonic. Unlike 12-ET and 19-ET, 15-ET matches the 11:8 and 16:11 ratios, and does not match the 7:5 or 10:7 tritone. 15-ET also has a neutral second and septimal whole tone. In order to construct a major third, one must stack two intervals of different sizes, whereas one can divide both the minor third and perfect fourth into two equal intervals.