Events

• January 19 - Treaty of Barcelona: Charles VIII of France returns Cerdagne and Roussillon to Ferdinand of Aragon.
• April - Christopher Columbus returns to Spain from his first voyage of discovery.
• May 4 - Pope Alexander VI decrees that all lands discovered west of the Azores are Spanish.
• August 19 - Maximilian I succeeds his father, Frederick III, as Holy Roman Emperor.
• September 29 - Christopher Columbus leaves Cadiz on his second voyage of exploration.

Births

• March 15 - Anne de Montmorency, Constable of France (d. 1567)
• June 5 - Justus Jonas, German Protestant reformer (d. 1555)
• September 28 - Agnolo Firenzuola, Italian poet (d. c. 1545)
• October 14 - Shimazu Tadayoshi, Japanese warlord (d. 1568)
• November 11 (or December 17 - Paracelsus, Swiss physician and scientist (d. 1541)
• November 12 - Bartolommeo Bandinelli, Italian artist and sculptor (d. 1560)
• date unknown
• Simon Grynaeus, German scholar and theologian (d. 1541)
• Takeda Nobutora, Japanese warlord (d. 1573)
• Matsudaira Shigeyoshi, Japanese general (d. 1580)
• probable
• Jean du Bellay, French cardinal and diplomat (d. 1560)
• Robert Maxwell, 4th Lord Maxwell, Scottish statesman (d. 1546)

Deaths

• May 10 - Colin Campbell, 1st Earl of Argyll, Scottish politician (b. c. 1433)
• June 14 - Ermolao Barbaro, Italian scholar (b. 1454)
• August 19 - Frederick III, Holy Roman Emperor (b. 1415)
• September 9 - Mirko Derenčin, Croatian leader
• November - Martin Alonzo Pinzón, Spanish navigator and explorer (b. c. 1441)
• November 6 - Andrey Bolshoy, Russian prince (b. 1446)
• date unknown
• James Blount, English soldier
• James Douglas, 1st Earl of Morton
• Pietro Antonio Solari, Italian architect (b. 1450)
• Tupac Inca Yupanqui, Inca ruler of Tahuantinsuyu