On each show, guests from the comedy world, such as comedians, comedy writers and critics talked about what was going on in comedy that week. They reviewed shows on television, radio and new DVD and Audio releases.
Listeners could also contact the show to voice their opinions via the programme's website. Each week, some emails and posts on the BBC7 messageboard were read out by Ince. Also, members of the public could send in their own comedy recommendations. Several times, no-one sent in any recommendations, so they asked one of the Serious About Comedy staff to give theirs instead; this feature was dropped in the fifth (and final) series.