In 1968 they recorded a version of Percy Sledge's "When a man loves a woman", and the company Mandioca organized an audition for them in the Payró theatre. The members of Manal and Almendra were also present, and a few hours later they played together. In 1970 they recorded for Mandioca their first album Caliente.
In the B.A. Rock Festival Vox Dei played the first part of the theme "Genesis", which had no lyrics yet. In February 1971 they released La Biblia ('The Bible'). Being the first Argentine concept album, it became a turning point in the history of Argentine rock; even the Archdiocese, that had asked to examine the lyrics, recommended young people to buy it. Right after the recording of La Biblia, Jorge Godoy left the band and was replaced by Ignacio Smilari.
In 1972 they re-edited their first album and recorded the third one, Jeremías Pies de Plomo. During the first shows after the release, they recorded La Nave Infernal and a few months later Es una Nube, No Hay Duda. After Vox Dei para Vox Dei of 1974, Ricardo Soulé announced he would leave the band to start as a soloist. Carlos Michelini replaced him while recording Estamos en la pecera in 1975, and then was himself replaced by Raúl Fernandez. In 1976 they recorded Ciego de siglos.
Soulé returned to the band in 1978 to record Gata de noche. Slowly the differences between the musicians started to grow, but they respected the contract that kept them together until 1981. In 1988 they made a "come back", to produce Tengo Razones Para Seguir with Luis Valenti. The other albums recorded following the dissolution of the band are: Sin Darle Ya Más Vueltas in 1994, La Biblia II and El Camino.